Masamichi Hirose Selected Research

Sodium-Glucose Transporter 1

10/2021	Mizagliflozin, a selective SGLT1 inhibitor, improves vascular cognitive impairment in a mouse model of small vessel disease.
1/2020	SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease.
9/2018	Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice.
1/2018	[Roles of Sodium-Glucose Cotransporter 1 (SGLT1) in the Induction of Cardiac Remodeling].

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Masamichi Hirose Research Topics

Disease

8	Heart Failure 01/2020 - 01/2009
6	Fibrosis (Cirrhosis) 01/2022 - 01/2012
5	Ischemia 01/2020 - 01/2011
5	Ventricular Tachycardia 04/2015 - 06/2008
5	Tachycardia (Tachyarrhythmias) 01/2015 - 12/2003
4	Cardiomegaly (Heart Hypertrophy) 01/2022 - 03/2011
4	Hypertrophy 05/2021 - 01/2014
4	Atrial Fibrillation 12/2019 - 12/2002
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2021 - 01/2016
3	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2014
3	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2014 - 01/2011
2	Body Weight (Weight, Body) 10/2021 - 09/2018
2	Dyslipidemias (Dyslipidemia) 10/2021 - 01/2020
2	Myocardial Infarction 01/2020 - 04/2015
2	Obesity 12/2019 - 01/2016
2	Atrial Remodeling 01/2019 - 01/2009
2	Cardiac Arrhythmias (Arrythmia) 01/2014 - 01/2012
1	Non-alcoholic Fatty Liver Disease 10/2021
1	Atherosclerosis 10/2021
1	Cognitive Dysfunction 10/2021
1	Ventricular Remodeling 01/2020
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 09/2018
1	Diabetes Mellitus 12/2017
1	Starvation 12/2017
1	Infarction (Infarctions) 04/2015
1	Timothy syndrome 06/2012
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2012
1	Blepharoptosis (Ptosis, Eyelid) 05/2010
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 06/2008
1	Heart Diseases (Heart Disease) 06/2008
1	Left Ventricular Dysfunction 06/2008
1	Reperfusion Injury 06/2008
1	Premature Cardiac Complexes (Extrasystoles) 01/2007
1	Bradycardia 07/2002

Drug/Important Bio-Agent (IBA)

4	Sodium-Glucose Transporter 1IBA 10/2021 - 01/2018
4	Adrenergic Agents (Adrenergic Drugs)IBA 09/2018 - 01/2007
4	Nicorandil (SG 75)IBA 01/2014 - 06/2008
3	Adenosine Triphosphate (ATP)IBA 01/2015 - 06/2008
3	Polyvinyl Chloride (PVC)IBA 01/2014 - 01/2011
2	Interleukin-18 (Interleukin 18)IBA 01/2022 - 09/2018
2	PhlorhizinIBA 10/2021 - 01/2014
2	salicylhydroxamic acid (SHAM)IBA 01/2020 - 09/2018
2	Cholinergic Agents (Cholinergics)IBA 02/2014 - 01/2007
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 04/2012 - 03/2011
2	Diacylglycerol KinaseIBA 01/2011 - 01/2009
1	HDL CholesterolIBA 10/2021
1	LDL CholesterolIBA 10/2021
1	Triglycerides (Triacylglycerol)IBA 10/2021
1	mizagliflozinIBA 10/2021
1	Cell Adhesion MoleculesIBA 05/2021
1	RNA (Ribonucleic Acid)IBA 05/2021
1	CD146 AntigenIBA 05/2021
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	3- (3- (4- (3- (glucopyranosyloxy)- 5- isopropyl- 1H- pyrazol- 4- ylmethyl)- 3- methylphenoxy)propylamino)propionamideIBA 01/2020
1	SodiumIBA 01/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2020
1	SymportersIBA 01/2020
1	AcidsIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Eicosapentaenoic AcidIBA 01/2020
1	LDL Receptors (LDL Receptor)IBA 01/2020
1	Connexin 43 (Connexin43)IBA 12/2019
1	Perilipin-2IBA 12/2019
1	InflammasomesIBA 01/2019
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 09/2018
1	LipidsIBA 12/2017
1	LigandsIBA 01/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2016
1	Coloring Agents (Dyes)IBA 04/2015
1	1,3-dipropyl-8-cyclopentylxanthineIBA 02/2014
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 02/2014
1	Atropine FDA LinkGeneric 02/2014
1	Purinergic P1 Receptors (Adenosine Receptor)IBA 02/2014
1	olmesartanIBA 01/2014
1	DesminIBA 01/2014
1	Type 1 Angiotensin ReceptorIBA 01/2014
1	Angiotensin IIIBA 01/2014
1	1,4-dihydropyridine (dihydropyridine)IBA 06/2012
1	Nifedipine (Adalat)FDA LinkGeneric 06/2012
1	Proteins (Proteins, Gene)FDA Link 04/2012
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 03/2011
1	Protein Kinases (Protein Kinase)IBA 03/2011
1	ABT 866IBA 05/2010
1	DiglyceridesIBA 01/2009
1	GTP-Binding Proteins (G-Protein)IBA 01/2009
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 06/2008
1	Cardiac MyosinsIBA 06/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2008
1	pilsicainideIBA 11/2007
1	rotigaptideIBA 07/2006
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 12/2003
1	Botulinum Toxins (Botulinum Toxin)IBA 07/2002

Therapy/Procedure

2	Therapeutics 01/2020 - 12/2019
1	Transplantation 04/2015
1	Aftercare (After-Treatment) 07/2006
1	Denervation 12/2002